For the first time in this cycle St Francis bears a tonsure and is dressed in the simple brown habit of a Franciscan, with a cord as a belt. This plain habit clearly distinguishes him from St Dominic, whose habit is a white tunic with a white scapular with a dark cape over it. In contrast with the rather more lavish Dominican attire, St Francis' simple habit refers to the ideal of poverty to which he dedicated himself for the rest of his life.
The two founders of orders met in Rome, as indicated by the obelisks which appear on the left side of the church. Benozzo places the scene, which according to legend took place in 1215, in front of a church, presumably Old St Peter's. This scene is not drawn from the legend of St Francis but from the life of St Dominic in the "Legenda Aurea" (Golden Legend).
The accompanying inscription reads: QUANDO BEATA VIRGO OSTE(N)DIT XPO BEATU(M) FRANCISCU(M) ET BEATU(M) DOMINICU(M) PRO REPARATIONE MUNDI - "How the blessed Virgin pointed St Francis and St Dominic out to Christ, for the renewal of the world." This picture concludes the bottom row of the pictures on the right southern wall.